Bicyclic Pyrazinone Derivatives

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专利权人:

Merck Patent GmbH

发明人:

DORSCH, Dieter,BUCHSTALLER, Hans-Peter,MOINET, Gérard,WEGENER, Ansgar

申请号：

ES13712685

公开号：

ES2585044T3

申请日:

2013.03.19

申请国别(地区):

ES

年份:

2016

代理人:

摘要：

Compounds of the formula I ** Formula ** in which R1 denotes H, F, Cl, CN, CH3, CH2OH, CH2Cl, CH2Br, CF3, CHF2 or CH2F, R2 denotes H or A, R3 denotes H, F, Cl , CH3, CF3 or CHF2, X denotes CR3 or N, Y denotes Ar1, Carb, Het1 or Cyc, Ar1 denotes phenyl or naphthyl that is unsubstituted or is mono, di or trisubstituted with Hal, [C (R2) 2] pOR2 , [C (R2) 2] pN (R2) 2, [C (R2) 2] pHet2, NO2, CN, [C (R2) 2] pCOOR2, [C (R2) 2] pCON (R2) 2, NR2COA , NR2SO2A, [C (R2) 2] pSO2N (R2) 2, S (O) nA, COHet3, O [C (R2) 2] mN (R2) 2, O [C (R2) 2] pAr2, O [ C (R2) 2] pHet2, NHCOOA, NHCON (R2) 2, Cyc, CHO and / or COA, Ar2 denotes phenyl, which is unsubstituted or mono- or disubstituted by Hal, A, [C (R2) 2] pOR2 , [C (R2) 2] pN (R2) 2, [C (R2) 2] pHet3, NO2, CN, [C (R2) 2] pCOOR, [C (R2) 2] pN (R2) 2, N (R2) 2COA, NR2SO2A, [C (R2) 2] pSO2N (R2) 2, S (O) nA, COHet3, O [C (R2) 2] mN (R2) 2, O [C (R2) 2] pHet3, NHCOOA, NHCON (R2) 2, CHO and / or COA, Het1 denotes pyrrolidinyl, azetidinyl, tetrahydroimidazolyl, tetrahydrofuranyl, tetrahydropyrazolyl, tetrahydropyranyl, piperidinyl, morpholinyl, hexahydropyridazinyl, he xahidropyrimidinyl, [1,3] dioxolanyl, piperazinyl, furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyrimidyl, pyridazinyl, indolyl, isoindzolyl, benzylazole, quinindolyl, benzylazole, quinindolyl, benzylazole, quinindolyl, benzyl imidazolyl, quinimidazole, quinindolyl, benzyl imidazolyl, quinimidazole, quinindolyl, benzyl imidazolyl , 3-benzodioxolyl, benzothiophenyl, benzofuranyl, imidazopyridyl or furo [3,2- b] pyridyl, each of which is unsubstituted or mono- or disubstituted by Hal, A, [C (R2) 2] pOR2, [ C (R2) 2] pN (R2) 2, [C (R2) 2] pHet2, [C (R2) 2] pAr2, NO2, CN, [C (R2) 2] pCOOR2, [C (R2) 2] pCON (R2) 2, NR2COA, NR2SO2A, [C (R2) 2] pSO2N (R2) 2, S (O) nA, COHet3, O [C (R2) 2] mN (R2) 2, O [C (R2 ) 2] pAr2, O [C (R2) 2] pHet2, NHCOOA, NHCON (R2) 2, CHO, COA,>； = S,>； = NR and / or&g

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