LINDEN LARS,GREVEN SIMONE,HARRENGA AXEL,FREIBERG CHRISTOPH,OTTO CHRISTIANE,TRAUTWEIN MARK,WILMEN ANDREAS
申请号：
NZ61831612
公开号：
NZ618316A
申请日:
2012.05.31
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is an antibody or antigen-binding fragment thereof which antagonises prolactin receptor-mediated signalling, whereby the antibody or antigen-binding fragment thereof comprises a variable heavy chain containing the CDR sequences of FSSYWMHW, SDIARLSSYTNYADSVKGR, and ARGLDARRMDY and a variable light chain containing the CDR sequences of TGSSSNIGAGYVVH, RNNQRPS, and CAAWDDSLNGWL. Also disclosed is the use of the above-described antibody or antigen-binding fragment in preparation of a medicament for the treatment and/or prevention of endometriosis and adenomyosis, benign breast disease and mastalgia, or anti-oestrogen-resistant breast cancer.
