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Crystal of pyrrole derivative and method for producing the same
专利权人:
Daiichi Sankyo Company; Limited
发明人:
Masashi Watanabe,Takahiro Okachi,Michiaki Kawahara,Hiroshi Nagasawa,Noritada Sato,Takashi Takita,Gen Hasegawa
申请号:
US14879814
公开号:
US09499483B2
申请日:
2015.10.09
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention provides a production intermediate of an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, a method for producing the same, and a crystal thereof. A method for producing an atropisomer of a pyrrole derivative including a step of resolving a compound represented by the following general formula (I) [wherein R1 represents a methyl group or a trifluoromethyl group, R2 represents a hydrogen atom or a C1-C3 alkoxy group, and n represents an integer selected from 1 to 3] into its atropisomers, characterized by using an optically active amine having a cinchonine skeletal formula, and a crystal of (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide.
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