The present invention relates to the compound of formula A and B and its pharmaceutically acceptable salt: and wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined in description. The invention additionally relates to the methods for the disease that the pharmaceutical composition for including the compound and pharmaceutically acceptable salt and treatment diabetes and its complication, cancer, ischemic, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease and skin disease pression, virosis, inflammatory conditions or in which liver are target organ.本發明涉及式A和B的化合物及其藥學可接受的鹽：和其中A，B，R1，R2，R3，R4，R5，R6，R7，R8，R9和R10如說明書中定義的。本發明另外涉及包括所述化合物和藥學可接受的鹽的藥物組合物以及治療糖尿病及其併發症、癌症、缺血、炎症、中樞神經系統病症、心血管疾病、阿爾茨海默氏病和皮膚病pression、病毒病、炎症性病症、或其中肝臟爲目標器官的疾病的方法。
