Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating immunological disorders, cardiovascular disease, cancer, and other diseases, disorders or conditions associated with PI3Kδ.揭露了具有式1之化合物,及其藥學上可接受之鹽,其中R1、R2、R3、R4、R5、R6、R7、R8、R9以及R10定義於說明書中。本揭露還涉及用製備具有式1之化合物之材料與方法,涉及包含它們的藥物組成物,並且涉及它們用於治療免疫障礙、心血管疾病、癌症以及其他與PI3Kδ相關的疾病、障礙或病症之用途。
