It consists of the substance represented by the formula (1),1. A pharmaceutically acceptable drug vehicle and a dissolving agent, which can help to improve the solubility, oral absorption characteristics and / or blood absorption characteristics of tetracycline compounds with ALK inhibitory activity insoluble or insoluble in water, as a preventive agent and / or Treatment for cancer, depression and cognitive disorders - Requirement 1: an ingredient characterized by a formula (1),a pharmaceutically acceptable vehicle, and a dissolution aid, [where, A1, A2, A3, A4, A7, A8, A9 and A10 represent all C, or any of A2, A3, A4, A7, A8 and A9 represents N ( with the proviso that, when it represents N, it has no substituent group) and the rest represent C； A5 is selected from NR5, O, and S； R1 and R10 independently represent [1] a hydrogen atom, [2] a cyano group, [3] a halogen atom or [4] a 4-10 membered heterocycloalkyl group which may be substituted by one or more heterocycloalkyl groups of between 4 and 10 members；R2 is selected from the following groups: (1) hydrogen atom, (2) c1-8 tar group, (3) oxidation C2-8 tar group, (4) C2-8 tar group, (5) cyanogen group, (6) halogen atom, (7) m2 amino group (c1-8 tar), which can be replaced by one or more c1-8 tar groups, M2: 0 ~ 2, Y (8) one nitrogen group； R3 is selected from the group consisting of: (1) hydrogen atom, (2) one c1-8 tar group, which can be replaced by [1] one or more halogen atoms, [2] one or more hydrogen Xi groups or [3] one or more alcoxi c1-8 groups, (3) one arilo C6-10 group, (4) one cyanogen group,(5) C1-8 alkane group, which can be replaced by one or more arilo C6-10, (6) m3a carbamate (tar c1-8) groups, which can be replaced by one or more R3a, R3a: [1] arilo C6-10, [2] c1-8 alkane group, [3] 5 to 14 member heteromorphic groups, or [4] arilsulfonilo C6-10, m3a: 0 ~ 2, (7) One carbon hydroxide (8) group c1-8 can be replaced by [1] one or more hydrogen Xi groups or [2] one or more alcoxi groups c1-8, (9) on
