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Iminoazúcares N- (5 - ((aryl or heteroryl) methyloxy) pentyl) -substituted as glucosylceramide synthase inhibitors
专利权人:
Universiteit Leiden;Academisch Medisch Centrum
发明人:
OVERKLEEFT, Herman Steven,VAN BOECKEL, Stan,AERTS, Johannes Maria Franciscus Gerardus,GHISAIDOOBE, Amar,VAN DEN BERG, Richard
申请号:
ES15719845
公开号:
ES2687843T3
申请日:
2015.03.23
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of general structure I: wherein: - each of R19-R26 is independently selected from H, F, Me or Et; - R27 and R28 are independently selected from the group consisting of H, F, CF3 and linear or branched C1-C8 alkyl; - X is where - Y1-Y5 are independently selected from the group of atoms of C and N with the proviso that no more than two of Y1-Y5 are an atom of N, and with the proviso that if one or two of Y1-Y5 are an atom of N, the group R anchored to that atom of N is empty; - Y6-Y9 are independently selected from the group of atoms of C, S, N and O and comprise at least one of the atoms of S, N or O, with the proviso that Y6-Y9 comprise at most one atom of S, at most one atom of N and / or at most one atom of O, and with the proviso that if one of Y6-Y9 is an atom of S or O, the group R anchored to any atom of S, N and / or Or it is empty, and with the proviso that if none of Y6-Y9 is an atom of S or O, the group R anchored to any atom of N is selected from the group consisting of H, linear or branched C1-C8 alkyl, IV and V, and with the proviso that the atoms of O and S are not present simultaneously; one of R1-R9 is ** Formula ** and the rest of R1-R9 are independently selected from the group consisting of H, F, Cl, Br, I, CN, CF3, linear and branched C1-C8 alkyl and C1 oxyalkyl -C8 linear or branched; wherein - Y10-Y14 is independently selected from the group of atoms of C and N with the proviso that no more than two of Y10-Y14 are an atom of N, and with the proviso that if one or two of Y10-Y14 they are an atom of N, the group R anchored to that atom of N is empty; - Y15-Y18 are independently selected from the group of atoms of C, S, N and O and Y19 is selected from the group consisting of an atom of C and an atom of N, with the proviso that Y15-Y19 comprises at most one atom of S, at most one atom of N and / or at most one atom of O, with the proviso that if one of Y15-Y19 is an atom of S or O, the group anchored to any atom of S, N and / or O is emp
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