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New derivatives of pyrimidine as phosphodiesterase 10 (PDE-10) inhibitors
专利权人:
PALOBIOFARMA S.L.
发明人:
CAMACHO GOMEZ, Juan,CASTRO PALOMINO LARIA, Julio
申请号:
ES14703553
公开号:
ES2611170T3
申请日:
2014.01.23
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compound of formula (I): ** Formula ** in which: - R1 is selected from the group consisting of hydrogen, halogen, cycloalkyl and alkyl of three or four carbon atoms, linear or branched - Y is selected from the group that it consists of C-R2 and a nitrogen atom; - R2 is selected from the group consisting of: a) an aryl or heteroaryl group which is optionally substituted by one or more halogen atoms or by one or more cycloalkyl, hydroxy, (C1-C8) alkoxy, (C1-C8) alkylthio groups ), amino, mono- or dialkylamino, alkoxyalkyl, hydroxycarbonyl and alkoxycarbonyl. b) an alkoxycarbonyl group of the formula (-CO (R7), where R7 represents a hydroxyl group or a group [-N (R8) (R9)]; R8 and R9 are independently selected from the group consisting of hydrogen atom, cycloalkyl , and alkyl of three or four carbon atoms, linear or branched and optionally substituted by halogen or an aryl or heterocyclic group; or R8 and R9 form, together with the nitrogen atom to which a saturated ring of five or six members are attached optionally comprising an additional heteroatom selected from the group consisting of oxygen and nitrogen that may be optionally substituted by a (C1-C8) alkyl group; - R3 is selected from the group consisting of hydrogen, halogen, cycloalkyl group and an alkyl group ( C1-C8), linear or branched optionally substituted by halogen atoms; or R2 and R3 form, together with the carbon atoms to which they are attached, a six-membered aryl or heteroaryl ring, optionally substituted by a or or more halogen atoms or by one or more groups selected from the group consisting of cycloalkyl, hydroxy, (C1-C8) alkoxy, (C1-C8) alkylthio, amino, mono or dialkylamino, alkoxyalkyl, hydroxycarbonyl and alkoxycarbonyl; - X is selected from the group consisting of halogen atom or cyano group; - R4, R5 and R6 are independently selected from the group consisting of: a) hydrogen atom b) an alkyl, cycloalkyl or cycloalkylalkyl group having a maximum of five carbon atoms, linear or branched subst
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