EASTWOOD PAUL ROBERT,BACH TAA JORDI,PAGES SANTACANA LLUIS MIQUEL
申请号：
ARP120102737
公开号：
AR087355A1
申请日:
2012.07.27
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
A procedure is described for their preparation, Pharmaceutical compositions containing same and their use in therapy as inhibitors of Janus Kinase (JAK).Claim 1: a compound of formula (1) or a pharmaceutically acceptable Salt or solvate or stereoisomer n-oxide or deuterated or derivative thereof, wherein: M is 0, 1, 2 or 3； each of X and y separately represents a nitrogen Atom or a Group - CR6,Where at least one of X and y represents a Group - Cr6； each of a and B independently represents a nitrogen Atom or a Group - CR7, where at least one of a and B represents a Group - CR7； d represents a nitrogen Atom or a Group - CR5, where when one a and B represents a NITROGEN Atom,D represents CR5 Group； W represents a group selected from the Group nr8 Linker - -, a Group - (cr9r10) -, - or - or - S -, R1 represents a hydrogen Atom, a linear or branched alkyl group C1 - 6, a group haloalquilo c1-4, a group hidroxialquilo C1 - 4, a c1-4 alkoxy Group, a Group Cycle C3 alkyl - 10, a group cicloalquenilo C3 - 10, a monocyclic or bicyclic aryl Group C6 14A heteroaryl Group 5 to 14 Member contains at least a heteroatom selected from o, s and N, or a Heterocyclic Group 5 to 14 Member contains at least a heteroatom selected from o, s and N, where groups cicloalquenilo, cycloalkyl, aryl, heteroaryl and heterociclilo e Are unsubstituted or substituted with one or more substituents selected from a Halogen Atom,A cyano Group, a linear or branched alkyl group C1 - 6, a group haloalquilo c1-4, a group hidroxialquilo c1-4, a Group alquilsulfonilo 4 C1 - C3 - 7, a cycloalkyl Group, a phenyl Group, a group piridilo pirimidinilo, a group or a group piperidilo； each of R2 and R6 regardless repr You have a hydrogen Atom, an atom of halogen, a cyano Group,A linear or branched alkyl group C1 - 6, a group haloalquilo c1-4, a group hidroxialquilo C1 - C3 - 4, a cycloalkyl Group, a group cicloalquenilo C3 - 10, an aryl Group monocyclic or bicyclic heteroaryl C6 14, a group of 5 to 14 Member contains
