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Selective triazole-triazine derivatives dependent on cyclin kinase inhibitors
专利权人:
Lead Discovery Center GmbH
发明人:
EICKHOFF, Jan,ZISCHINSKY, Gunther,KOCH, Uwe
申请号:
ES13707008
公开号:
ES2583231T3
申请日:
2013.03.01
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
The compound of the general formula (I) ** Formula ** where R1 represents -H or -CH3; R2 represents -R8, -Q-R8, -R9, -Q- (CH2) n-R9, - (CH2) n-R9, - (CH2) n-NH-R8, - (CH2) m-NH- (CH2) n-R9, -CO- ** Formula ** R3 represents ** Formula ** ii) C1-C8-linear or branched alkyl, C3-C8-cycloalkyl, C1-C9-heterocyclyl, C2-C8- linear or branched alkenyl, C2-C8-linear or branched alkynyl, C6-C14-aryl, C1-C10-heteroaryl, where the aforementioned residues can be substituted with 1 to 5 substituents selected from Z8, Z9, Z10, Z11 and Z12 ; iii) 3-membered heterocyclyl, 4-membered heterocyclyl, 5-membered heterocyclyl, 6-membered heterocyclyl, 4-membered monounsaturated heterocyclyl, 5-membered monounsaturated heterocyclyl, 6-membered monounsaturated heterocyclyl, 3-membered carbocyclyl, 4-membered carbocyclyl 5-member carbocyclyls, 6-member carbocyclyls, 6-member aryls, 5-member heteroaryls, 6-member heteroaryls, where all the aforementioned annular systems can be substituted with 1 to 4 substituents selected from Z1, Z2, Z3 and Z4 ; Z1 and Z2 if they were attached to the same carbon atom together can represent>; = O to form a carbonyl group with the carbon atom to which Z1 and Z2 are attached; R3 together with R4 can form a 4, 5, 6 or 7-membered carbocyclic or heterocyclic ring with the 2 carbon atoms of the benzo ring to which R3 and R4 are attached and that 4, 5, 6 or 7 member ring can be partially saturated or unsaturated and can be substituted with 1 to 4 substituents selected from Z1, Z2, Z3 and Z4; Z1 and Z2 if adhered to the same carbon atom can together represent>; = O to form a carbonyl group with the carbon atom to which Z1 and Z2 are attached; R4-R7 independently represent each other at -H, -F, -Cl, -CH3; R8 represents - (CH2) p-NH2, - (CH2) pN (R16R17), carbocyclyls, heterocyclyls, spirocarbocyclyls, spiroheterocyclyls, where the carbocyclyl, heterocyclyl, spirocarbocyclyl and spiroheterocyclyl residues already mentioned are linked through ano carbon they can be s
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