ZHANG, JIAZHONG,IBRAHIM, PRABHA N.,BREMER, RYAN,SPEVAK, WAYNE,CHO, HANNA
申请号：
CA2780190
公开号：
CA2780190C
申请日:
2010.11.04
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
Compounds of formula II and salts thereof, formulations thereof, conjugatesthereof,derivatives thereof, forms thereof and uses thereof are described. In certainaspects andembodiments, the described compounds or salts thereof, formulations thereof,conjugatesthereof, derivatives thereof, or forms thereof are active on Fms proteinkinase, or on Fms andKit protein kinase, or on Fms and Flt-3 protein kinase. Also described aremethods of usethereof to treat diseases and conditions, including diseases and conditionsassociated withactivity of Fms protein kinase, Kit protein kinase, or Flt-3 protein kinaseincludingrheumatoid arthritis, osteoarthritis, multiple sclerosis, Alzheimer's disease,Parkinson'sdisease, glomemlonephritis, interstitial nephritis, Lupus nephritis, tubularnecrosis, diabeticnephropathy, renal hypertrophy, acute myeloid leukemia, melanoma, multiplemyeloma,metastatic breast cancer, prostate cancer, pancreatic cancer,neurofibromatosis, brainmetastases, and gastrointestinal stromal tumors.(see formula II)
