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Liquid compositions for soft-release capsules and their manufacturing process
专利权人:
Paris; Laurence
发明人:
Paris, Laurence
申请号:
ES03740610
公开号:
ES2671843T3
申请日:
2003.04.15
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Liquid compositions in the form of prolonged-release capsules intended for the oral route, characterized in that they comprise: (i) at least one liquid matrix agent that belongs to the family of inverse latexes consisting of derivatives of acrylic acid or polymers of acrylamide (ii) at least one active ingredient (iii) a solubilizing or dispersing solvent for the active ingredient (iv) and at least one excipient that modulates the release kinetics of the active ingredient the aforementioned excipients that modulate release are composed of : a) hydrophilic adjuvants belonging to the class of celluloses and their derivatives, starches and their derivatives, polysaccharides such as guar gums, xanthan, tragacanth, arabica, carob, pectins, alginates, carrageenans, gelanes, chitosan, vinylpyrrolidone polymers, b) plasticizers, c) surfactants, d) solution accelerators, e) buffer systems, or a combination d e all five, which leads to a prolonged release of the active ingredient over a period of between 1 to 24 hours due to the formation in situ of a viscous network with a soft consistency to a hard consistency that has a gelatinous appearance or a solid network with spongy form (sponge appearance) with a more or less rigid structure, by instantaneous physical modification of said liquid matrix agent in contact with the digestive juices at the time of opening the capsule.Composiciones líquidas en forma de cápsulas de liberación prolongada destinadas a la vía oral, caracterizadas por el hecho de que comprenden: (i) al menos un agente matricial líquido que pertenece a la familia de los látex inversos constituidos por derivados del ácido acrílico o por polímeros de acrilamida (ii) al menos un principio activo (iii) un disolvente de solubilización o dispersión del principio activo (iv) y al menos un excipiente que modula la cinética de liberación del principio activo los excipientes mencionados anteriormente que modulan la liberación están compuestos por: a) adyuvantes hidrófilo
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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