NOVEL 4-(AZACYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, METHOD FOR PRODUCTION THEREOF AND USE THEREOF IN HUMAN TREATMENT AND IN COSMETICS

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专利权人:

GALDERMA RESERCH EHND DEVELOPMENT

发明人:

BUATO Zhan-Gi (FR),БУАТО Жан-Ги (FR),BUKE Karin (FR),БУКЕ Карин (FR),TALANO Sandrin (FR),ТАЛАНО Сандрин (FR),MILLUA BARBJuI Korinn (FR),МИЛЛУА БАРБЮИ Коринн (FR),BUATO ZHAN-GI,БУАТО Жан-Ги,BUKE KARIN,БУКЕ Карин,TALANO SANDRIN,ТАЛАНО Сандрин,MILLUA BARBJUI KORINN,МИЛЛУА БАРБЮИ Коринн

申请号：

RU2011127126/04

公开号：

RU0002499794C2

申请日:

2009.12.02

申请国别(地区):

RU

年份:

2013

代理人:

摘要：

FIELD: chemistry.SUBSTANCE: invention relates to 4-(azacycloalkyl)benzene-1,3-diol compounds of general formula (I) given below:,where: R1 is: - C1-C5-alkyl radical, - C3-C6-cycloalkyl radical, - aryl radical, - aryl radical substituted with one or more groups selected from C1-C5 alkyl, and C1-C5 alkoxy group, a fluorine atom or a trifluoromethyl group, - aralkyl radical, - C1-C5-alkoxy radical, -amine radical, having the structure (a):,where R2 is: - hydrogen, - C1-C5-alkyl radical, - C3-C6- cycloalkyl radical, - aryl radical, - aryl radical substituted with one or more groups selected from C1-C5 alkyl, and C1-C5 alkoxy group, a fluorine atom and a trifluoromethyl group, - pyridyl radical, - aralkyl radical of the structure (b):,where p is equal to 1 or 2, - a radical of the structure (c):,where R4 is: - carboxymethyl, -COOCH3, or carboxyethyl, -COOEt, radical, - C1-C3-alkyl radica, - hydrogen, and R5 is: - an unsubstituted aryl radical or an aryl radical substituted with one or more groups selected from C1-C5 alkyl, C1-C5 alkoxy group, fluorine atom or a trifluoromethyl group, - C3-C6-cycloalkyl radical, - pyridyl, and R3 is: - hydrogen, - C1-C5-alkyl radical； or R1 can also be a radical of formula (d):,where R6 is: - hydrogen, - C1-C5-alkyl radical, - C3-C6-cycloalkyl radical, - aryl radical, - aryl radical substituted with one or more groups selected from C1-C5 alkyl, C1-C5 alkoxy group, a fluorine atom and a trifluoromethyl group, - pyridyl radical, - aralkyl radical, R7 is: - hydrogen, - C1-C5-alkyl radical, and R8 is: - hydrogen, - hydroxyl, - amine radical, - C1-C3-alkoxy radical； Y is hydrogen or fluorine, and m and n are equal to 0, 1 or 2, as well as isomeric and enantiomeric forms of compounds of formula (I). The invention also relates to use of said compounds as a drug for treating pigmentation disorders.EFFECT: novel compounds, which can be used in pharmacology or cosmetology to treat or prevent pigmentation disorders, are obtained and described.6 cl,

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