A compound of formula ** Formula ** a pharmaceutically acceptable salt by addition, a pharmaceutically acceptable solvate or a stereochemically isomeric form thereof, wherein: each of R1 is independently hydrogen； aryl； formyl； C1-6 alkylcarbonyl； C1-6 alkyl； C1-6-oxycarbonyl alkyl； R7 and R8 are independently hydrogen； hydroxy； halo； C3-7 cycloalkyl； C1-6-oxy alkyl； carboxyl； C1-6 alkyl oxycarbonyl； cyano； nitro； Not me； mono- or di- (C1-6 alkyl) amino； polyhalo-C 1-6 alkyl； polyhalo-C1-6-oxy alkyl； - C (>； = O) R10； C1-6 alkyl optionally substituted with halo, cyano or -C (>； = O) R10； C2-6 alkenyl optionally substituted with halo, cyano or -C (>； = O) R10； C2-6 alkynyl optionally substituted with halo, cyano or -C (>； = O) R10； R4 is cyano； R9 is C1-6 alkyl； C2-6 alkenyl； C2-6 alkynyl, each substituted with cyano； R5 is -C (>； = O) NR5aR5b； or -CH (OR5c) R5d or R5 is Het； wherein R5a is C1-6-oxy alkyl； C2-6 alkenyl； C3-7 cycloalkyl； or C1-6 alkyl substituted with hydroxy, amino, mono- or di (C1-6 alkyl) amino, C1-6 alkylcarbonylamino, halo, cyano, aryl, pyridyl, thienyl, furanyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, piperazinyl optionally substituted with C 1-6 alkyl, C 1-6 alkylcarbonyl or with hydroxyC 1-6 alkyl； or R5a is C1-6 alkyl substituted with one or two C1-6-oxy alkyl； R5b is hydrogen or C1-6 alkyl； or R5a and R5b taken together with the nitrogen atom of which they are substituents form pyrrolidinyl； piperidinyl optionally substituted with aminocarbonyl, hydroxy or with C1-6-oxy alkyl； morpholinyl； piperazinyl； piperazinyl optionally substituted with C1-6 alkyl, C1-6 alkylcarbonyl or with hydroxy C1-6 alkyl； R5c is hydrogen, C1-6 alkyl, Het； R5d is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl or Het； R6 is C1-6 alkoxy-C1-6 alkyl； each of R10, independently, is C1-6 alkyl, amino, mono- or di- (C1-6 alkyl) amino or polyhalo-C1-6 alkyl； X is -NR1-； each of r, independently, is 1 or 2； each of Het, independently,
