NOUVEAUX POLYPEPTIDES PRÉSENTANT UNE MEILLEURE STABILITÉ ET PROCÉDÉS DE PRÉPARATION ET D'UTILISATION ASSOCIÉS

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专利权人:

Tufts University;Tufts Medical Center, Inc.

发明人:

KUMAR, Krishna,MONTANARI, Vittorio,BEINBORN, Martin,RAMAN, Venkata

申请号：

EP16860981

公开号：

EP3368556A4

申请日:

2016.10.28

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group consisting of a N-terminus amino group, the NH group of the N-terminus first internal amide bond, another primary amino group, a thiol group and a thioether group within the polypeptide. The present invention further includes polypeptides incorporating such chemical modifications.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/