Novel polypeptides with improved proteolytic stability, and methods of preparing and using same

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专利权人:

Tufts Medical Center;Tufts University

发明人:

Kumar, Krishna,Montanari, Vittorio,Beinborn, Martin,Raman, Venkata

申请号：

AU2016343775

公开号：

AU2016343775A1

申请日:

2016.10.28

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group consisting of a N-terminus amino group, the NH group of the N-terminus first internal amide bond, another primary amino group, a thiol group and a thioether group within the polypeptide. The present invention further includes polypeptides incorporating such chemical modifications.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/