DIPIANO, GERIANNE TRINGALI,MAYS, PETER KEVIN,ZIEMNIAK, JOHN
申请号：
CA2511995
公开号：
CA2511995C
申请日:
2004.01.02
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Formulations for topical or local administration of drugs directly to thebreast or chest to produce a regional or local effect with lower systemic druglevels than when an effective amount is administered systemically aredisclosed herein. In a preferred embodiment, the drug is administered to thesurface of the breast, areola, or directly to the nipple. The formulationsprovide increased patient comfort, increased bioavailability and relativelyhigh blood levels in the region to be treated with a reduction of side effectscompared to those administered systemically. The preferred formulationscontain drugs in the form of micro or nanoparticles, which may be formed ofdrug alone or in combination with an excipient or carrier. The excipient orcarrier may modify the release rates or enhance absorption into the affectedarea. The drug formulation may be in the form of a cream, lotion of foam.
