您的位置: 首页 > 农业专利 > 详情页

Compound Antibacterial Agent, Pharmaceutical composition comprising IT, and Process for its preparation
专利权人:
ABAC THERAPEUTICS S.L.
发明人:
GARGALLO VIOLA, DOMINGO,PALOMER BENET, ALBERT
申请号:
ARP170102117
公开号:
AR109173A1
申请日:
2017.07.27
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
2 - pyrrolidin-3-yl fenilhidrazidas compounds are antibacterial, Targeted specifically against Acinetobacter baumannii.Also refers to their Therapeutic use as antibacterials, a process for their Preparation and Pharmaceutical compositions containing them.Claim 1: a compound Antibacterial Agent of formula (1) or a pharmaceutically acceptable Salt or solvate thereof,Wherein r¹ and R² are independently Hydrogen, alkyl c₁₋₄, haloalquilo c₁₋₄ and hidroxialquilo c₁₋₄ r³, r⁴, r⁵ r⁶ are selected independently, and r⁷ Hydrogen- Oh, halogen, alkoxy c₁₋₆, haloalcoxi c₁₋₄, - or - cicloalquil c₃₋₆alquilo c₀₋₄, c₁₋₆ cicloalquil c₃₋₆alquilo c₀₋₄, alkyl, alkoxy haloalquilo c₁₋₆, hidroxialquilo c₁₋₆, c₁₋₄alquilo c₁₋₆,C₁₋₄alcoxi c₁₋₄ ocor¹¹ alkoxy -, - os (O₂) r¹¹ nr¹¹r¹² nr¹¹cor¹² -, -, -, - nr¹¹co₂r¹², nr¹¹s (O₂) r¹² oconr¹¹r¹² conr¹¹r¹², -, -, - S - S nr¹¹r¹² (O₂), (r¹¹, O₂)- and CN - co₂r¹¹ or r³ r⁷ United to two adjacent carbon Atoms are connected to form a cycloalkyl of 5 or 6 members.Where 1 or 2 methylene groups can be replaced by the cycloalkyl orThis can be optionally substituted cycloalkyl alkyl or with one or more c₁₋₄ haloalquilo c₁₋₄ r⁸ is selected from alkyl - Oh, c₁₋₆, haloalquilo c₁₋₆, hidroxialquilo c₁₋₄,C₁₋₄alquilo c₀₋₄ alkoxy, cicloalquil c₃₋₆alquilo c₀₋₄, Acyl c₂₋₅, - C (o) cicloalquil c₃₋₆alquilo c₀₋₂ conr¹³r¹⁴ -, -, and - C (nr¹⁵) nr¹¹r¹² co₂r¹¹ r⁹ is selected from Hydrogen,C₁₋₄ and haloalquilo c₁₋₄ alkyl n is 0, 1, 2 or 3 each r¹⁰, IF present, is independently selected from - Oh, c₁₋₆ Halogen, alkyl, alkoxy haloalquilo c₁₋₆, c₁₋₆,C₁₋₄alquilo c₁₋₆ alkoxy - or - cicloalquil c₃₋₆alquilo c₀₋₄ sr¹¹ nr¹¹r¹², -, -, - ocor¹¹, - os (O₂) r¹¹, nr¹¹cor¹² nr¹¹co₂r¹² -, -, - nr¹¹s (O₂) r¹², - CN, - oconr¹¹r¹², phenylHeteroaryl Ring of 5 or 6 members comprising 1 or 2 heteroatoms selected from N,O and S where the phenyl heteroaryl Ring that can be optionally substituted with one or more alkyl c₁₋₄ or haloalquilo c₁₋₄ or two r¹⁰ attached to a carbon Atom, forming a common oxo
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充