MEDICAMENT POUR TRAITER LA GRIPPE CARACTERISE EN CE QU'IL COMPREND UNE COMBINAISON D'UN INHIBITEUR D'ENDONUCLEASE COIFFE-DEPENDANTE AVEC UN MEDICAMENT ANTIGRIPPAL
A) Formula (I) A medicine that is useful for treating or preventing influenza, etc., said medicine being characterized by comprising a combination of: (A) a compound represented by formula (I), a pharmaceutically acceptable salt thereof, or a solvate of the same [in formula (I): P represents a hydrogen atom or a prodrug-forming group； A1 represents CR1AR1B, S or O； A2 represents CR2AR2B, S or O； A3 represents CR3AR3B, S or O； A4's independently represent CR4AR4B, S or O； (wherein: the ring-constituting atoms of the ring formed by A1, A2, A3, A4's, the nitrogen atom adjacent to A1 and the carbon atom adjacent to A4's include 1 or 2 hetero atoms； R1A and R1B independently represent a hydrogen atom, halogen, alky, etc.； R2A and R2B independently represent a hydrogen atom, halogen, alky, etc.； R3A and R3B independently represent a hydrogen atom, halogen, alky, etc.； R4A's independently represent a hydrogen atom, halogen, alky, etc.； R4B's independently represent a hydrogen atom, halogen, alky, etc.； and R3A and R3B may form, together with the carbon atom adjacent thereto, a non-aromatic carbon ring or a non-aromatic heterocyclic ring)； n is an integer of 1-2； and R1 is a group represented by formula (2), etc.]； with (B) a compound having an anti-influenza effect, a pharmaceutically acceptable salt thereof, or a solvate of the same, and/or an antibody having an anti-influenza effect.
