USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR; V.V.I.
发明人:
Filip Teply,Miroslav Hajek
申请号：
US14655999
公开号：
US09340543B2
申请日:
2014.01.17
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention provides helquat derivatives of general formula I, wherein substituents R1 and R2 are independently selected from a group comprising H and C1 to C3 alkyl； up to three of S1,2, S1′,2′, S3,4 and S3′, 4′ are present, each of S1,2, S1′,2′, S3,4 and S3′,4′ independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms； one or two atoms selected from the carbon atoms with the descriptor 2, 4, 2′, and 4′ are substituted with a substituent R3 of general formula II or general formula III wherein R4 is substituted or unsubstituted aryl； T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms； and anions (X1)− and (X2)− independently represent anions of pharmaceutically acceptable salts.The helquat derivatives are useful as medicaments in the treatment of diseases related to increased cellular proliferation, such as oncologic diseases.
