V.V.I;USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR
发明人:
TEPLY, FILIP,HAJEK, MIROSLAV
申请号：
CA2895539
公开号：
CA2895539A1
申请日:
2014.01.17
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The invention provides helquat derivatives of general formula I, wherein substituents R1 and R2 are independently selected from a group comprising H and C1 to C3 alkyl； up to three of S1,2, S1',2', S3,4 and S3',4' are present, each of S1,2, S1',2', S3,4 and S3',4' independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms； one or two atoms selected from the carbon atoms with the descriptor 2, 4, 2', and 4' are substituted with a substituent R3 of general formula (II) or general formula (III) wherein R4 is substituted or unsubstituted aryl； T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms； and anions (X1)- and (X2)- independently represent anions of pharmaceutically acceptable salts. The helquat derivatives are useful as medicaments in the treatment of diseases related to increased cellular proliferation, such as oncologic diseases. ?
