The United States of America; Dept. of Health & Human Services; as represented by the Secretary
发明人:
Liyanage P. Perera,Thomas A. Waldmann,Sang-Kon Oh,Jay A. Berzofsky
申请号:
US14156105
公开号:
US20140377306A1
申请日:
2014.01.15
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The invention is directed to compositions capable of augmenting the immunogenicity of a vaccine. The composition, or adjuvant, is administered to a mammal in need thereof in sequential or concurrent combination with a vaccine antigen. In one preferred aspect, the adjuvant is provided in the form of a recombinant poxvirus vector, such as a vaccinia virus vector, which comprises a nucleic acid sequence encoding IL-15.