The present disclosure provides antibodies and antigen-binding fragments capable of binding PAR2. In some embodiments, the anti-PAR2 antibodies or antigen-binding fragments thereof bind PAR2 in a pH-dependent manner. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.本發明提供能夠結合PAR2之抗體及抗原結合片段。在一些實施例中,該等抗PAR2抗體或其抗原結合片段以pH依賴性方式結合PAR2。本發明進一步提供製造及使用該等抗體及抗原結合片段之方法。