The present invention relates to isolated antibodies and antigen-binding fragments thereof which selectively bind human CD32b. Also provided herein are compositions comprising the antibodies or antigen-binding fragments thereof, methods of using the antibodies or antigen-binding fragments thereof, and methods of making the antibodies or antigen-binding fragments thereof.本發明係關於選擇性結合人類CD32b之經分離抗體及其抗原結合片段。本文中亦提供包含該等抗體或其抗原結合片段之組合物、使用該等抗體或其抗原結合片段之方法及製造該等抗體或其抗原結合片段之方法。