The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human B7-H4 (and optionally cynomolgus monkey, mouse, and/or rat B7-H4) and compositions comprising such antibodies or antigen-binding fragments thereof. In a specific aspect, the antibodies or antigen-binding fragments thereof that specifically bind to human B7-H4 increase T cell proliferation, increase interferon-gamma production, and/or deplete B7-H4 expressing cells via ADCC activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering an antibody or antigen-binding fragment thereof that specifically binds to human B7-H4.本發明提供特異性結合至人類B7-H4(且視情況結合至食蟹獼猴、小鼠及/或大鼠B7-H4)的抗體及其抗原結合片段，以及包含此類抗體或其抗原結合片段之組成物。在一個特定態樣中，該等特異性結合至人類B7-H4之抗體或其抗原結合片段增加T細胞增殖，增加干擾素-γ產生及/或經由ADCC活性耗盡B7-H4表現細胞。本發明亦提供藉由投與特異性結合至人類B7-H4之抗體或其抗原結合片段來治療病症，諸如癌症的方法。
