NY SIN,ZHENG LIU,JACOB SWIDORSKI,SING SIT,JIE YUEN - CHEN,YAN CHEN,NICHOLAS A. MEANWELL,ALICIA REGUEIRO-REN
申请号：
ARP130101545
公开号：
AR090955A1
申请日:
2013.05.06
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
2. Compounds with pharmacological properties that affect the biological appearance, pharmaceutical ingredients and use methods. In particular, the single antiretroviral activity of dicyclotriene C-17 can inhibit the maturation of HIV. These compounds contribute to the treatment of HIV and AIDS. 1. Characteristic 1: a compound, including an acceptable salt (1) selected from one of the following groups with pharmaceutical characteristics；a. A formula compound (2)；And a formula compound (3)；In R1 is isopropyl or isopropyl； J and E are independent h-o-ch-83323；and E is absent when the double bond is present； X is selected from the group of phenyl, heteroaryl ring, C₄₋₈ cycloalkyl ring,cycloalkenyl C₄₋₈,Spirocycloalkyl C₄₋₉,Spirocycloalkenyl C₄₋₉,Cac oxacycloalkyl,dioxacycloalkyl C₄₋₈,1.Oxacicloalquenilo C832626dioxacycloalkenyl C₆₋₈,C832626 cyclomycinoxacyclodialkenyl C₆,oxaspirocycloalkyl C₆₋₉ and oxaspirocycloalkenyl C₆₋₉；X can also be selected from the formula group (4)；For compounds of formulas (2) and (3),X can also be a formula compound (5)；X is replaced by a, and a is at least one member selected from h-halo-hydroxy-c83218c8318326a；-alkoxy C₁₋₆,-Halide c83218c83331-832626；-Nr2,-Coorrow,-C (O) NR R-C (O) NR SO R-I'm 832222-No. 832222；-I'm 832222-cycloalkyl C₁₋₆-COOR²,-Alquenil c83228331-832626-coordination；-alquinyl C₂₋₆-COOR²,-alkyl C₁₋₆-COOR²,-NHC (O) (CH) -COOR-SO NR C (O) R-Tetrazol works with heterosexual bicycles and is selected from the group,-C (O) NR SO R-C (O) NHSO NR R-18322, - R3,-I'm 832222-cycloalkyl C₃₋₆-COOR²,-Alquenil c83228331-832626-coordination；-alquinyl C₂₋₆-COOR²,-alkyl C₁₋₆-COOR²,-NHC (O) (CH) -COOR-SO NR C (O) R-Tetrazol y-conhoh； n = 1-6； ws-ch8322o-co； Z was selected from formula group (6)；V from - cr8322； - r8313 -,-SO₂-,-O- and -NR¹⁰-；U from - cr8322； - r831393 -,-SO₂- and -NR¹⁰-；M selected from - chr8322； - r8313；-SO₂R⁴,-SO₂NR³R³,-OH and -NR¹⁰R¹¹-；R2 es-h, lease No. c1832131；C₁₋₆-alkyl substituted with -alkyl or C₁₋₆-alkyl substituted
