The present invention relates to the use of non-saponifiable moieties obtained from natural, plant and/or animal lipids, for the treatment of tumour diseases caused by the permanent (or chronic) alteration (or imbalance) of the normal physiological equilibrium of the steroidal balance in a patient suffering from this chronic condition. In particular, the invention relates to a pharmaceutical composition comprising said non-saponifiable moieties for use in the treatment of those tumour diseases, lung tumours and/or vulvar tumors and/or mammary tumors and/or shell carcinomas and/or melanomas, which are caused by permanent (or chronic) alteration (or unbalance) of the natural physiological equilibrium of the steroidal balance in a patient suffering from said pathology, and of the chronic lesions associated with the same which determine them. Said pharmaceutical composition is particularly adapted for transdermal and/or transmucosal topical administration.
