The present invention relates to the use of non-saponifiable moieties obtained from natural, plant and/or animal lipids, for the treatment of cardiac diseases caused by the permanent (or chronic) alteration (or imbalance) of the normal physiological equilibrium of the steroidal balance in a patient suffering from this chronic condition. In particular, the invention relates to a pharmaceutical composition of said non-saponifiable moieties for use in the treatment of those cardiac disorders, heart failure and/or cardiac arrhythmias and/or myocardial ischemic disease and/or atrioventricular dysfunction or valvulopathies, which are caused by permanent, chronic, pathological alteration of the natural physiological equilibrium of the steroidal balance in a patient suffering from said disease, and of the chronic lesions, either peripheral or not, associated with the same that determine them. Said pharmaceutical composition is particularly adapted for transdermal topical administration.
