STEVENS, PETER J.,STILWELL, REGINALD,SOUTHARD, MATTHEW JAMES,SAMANIEGO, ADRIAN C.
申请号：
CA3018119
公开号：
CA3018119A1
申请日:
2017.03.16
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Provided in this disclosure are various composite grafts having a trabecular scaffold with voids defined in at least a portion of the scaffold and a biological component positioned in at least some of the voids of the scaffold. The grafts may have a synthetic scaffold or a bone substrate scaffold. The grafts may be osteogenic, chondrogenic, osteochondrogenic, or vulnerary in nature. Also provided are methods of using the composite grafts to treat a tissue defect in a subject. Methods of manufacturing are also provided. Synthetic scaffolds are manufactured by additive manufacturing. Agitation is used to combine the biological component with the scaffold of the graft.
