BHAKTA, SUNIL,ERICKSON, HANS,JUNUTULA, JAGATH R.,KOZAK, KATHERINE,OHRI, RACHANA,PILLOW, THOMAS
申请号：
CA2957354
公开号：
CA2957354A1
申请日:
2015.09.11
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody； expressing the cysteine engineered antibody； and isolating the cysteine engineered antibody.
