Sunil BHAKTA,Hans ERICKSON,Jagath R. JUNUTULA,Katherine KOZAK,Rachana OHRI,Thomas PILLOW
申请号：
US16353207
公开号：
US20200017601A1
申请日:
2019.03.14
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody； expressing the cysteine engineered antibody； and isolating the cysteine engineered antibody.
