A method of screening is provided. In certain embodiments, the method involves a) obtaining the nucleotide sequences of: i. a heavy chain-encoding nucleic acid that encodes the variable domain of a heavy chain of a first antibody of an animal； and ii. a light chain-encoding nucleic acid that encodes the variable domain of a light chain of the first antibody； b) obtaining nucleotide sequences of cDNAs encoding at least a portion of the antibody repertoire of the animal； c) computationally screening the sequences obtained in b) to identify heavy and light chain sequences that are related by lineage to the heavy and light chain sequences of a)； and d) testing at least one pair of the heavy and light chain sequences identified in c) to identify a second antibody that binds to the same antigen as the first antibody.
