GENERATION OF ANTIBODIES TO TUMOR ANTIGENS AND GENERATION OF TUMOR SPECIFIC COMPLEMENT DEPENDENT CYTOTOXICITY BY ADMINISTRATION OF ONCOLYTIC VACCINIA VIRUS
David Kirn,John Bell,Caroline Breitback,Anne Moon,Tae-Ho Hwang,Yu Kyoung Lee,Mi-kyung Kim
申请号：
US13978113
公开号：
US20150037355A1
申请日:
2012.01.04
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to methods and compositions for use in inducing tumor-specific antibody mediated complement-dependent cytotoxic response in an animal having a tumor comprising administering to said animal a composition comprising a replication competent oncolytic virus wherein administration of the composition induces in the animal production of antibodies that mediate a CDC response specific to said tumor.
