GENERATION OF ANTIBODIES TO TUMOR ANTIGENS AND GENERATION OF TUMOR SPECIFIC COMPLEMENT DEPENDENT CYTOTOXICITY BY ADMINISTRATION OF ONCOLYTIC VACCINIA VIRUS
David KIRN,John BELL,Caroline BREITBACH,Anne MOON,Tae-Ho HWANG,Yu Kyoung LEE,Mi-kyung KIM
申请号：
US15892247
公开号：
US20180214538A1
申请日:
2018.02.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to methods and compositions for use in inducing tumor-specific antibody mediated complement-dependent cytotoxic response in an animal having a tumor comprising administering to said animal a composition comprising a replication competent oncolytic virus wherein administration of the composition induces in the animal production of antibodies that mediate a CDC response specific to said tumor.
