AMINA LAANAN,DOMINIQUE INGRID LEMOINE,LEONARD DODE,OLIVIER C GERMAY,OLIVIER PATRICK LE BUSSY,POL GUY HARVENGT,STEPHANE ANDRE GODART
申请号：
BR112014001052
公开号：
BR112014001052A2
申请日:
2012.07.20
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Methods and processes for the purification of PRAME are provided. In particular, methods for reducing the aggregation of PRAME during a diluent exchange from diluent A to diluent B comprising: (i) adding a polyanionic compound to diluent A prior to or contemporaneously with the exchange； and (ii) exchanging protein from diluent A to diluent B are provided. Compositions produced by the method are also provided.
