Dominique Ingrid Lemoine;Olivier C Germay;Stephane Andre Godart;Amina Laanan;Pol Guy Harvengt;Olivier Patrick Le Bussy;Leonard Dode
发明人:
Olivier C Germay,Stephane Andre Godart,Pol Guy Harvengt,Amina Laanan,Olivier Patrick Le Bussy,Dominique Ingrid Lemoine,Leonard Dode
申请号：
US14234111
公开号：
US20140234424A1
申请日:
2012.07.20
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Methods and processes for the purification of PRAME are provided. In particular, methods for reducing the aggregation of PRAME during a diluent exchange from diluent A to diluent B comprising: (i) adding a polyanionic compound to diluent A prior to or contemporaneously with the exchange； and (ii) exchanging protein from diluent A to diluent B are provided. Compositions produced by the method are also provided.
