YU, HA NA,BAIK, HYE JUNG,YANG, WON KYU,KO, JIN YOUNG,JUNG, SUNG BUM,AN, SUNG WON,KI, MIN HYO
申请号：
EP13866593
公开号：
EP2938331A4
申请日:
2013.12.27
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
Disclosed is a sustained-release lipid pre-concentrate, comprising: a) at least one liquid crystal former b) at least one neutral phospholipid c) at least one liquid crystal hardener and d) at least one anionic anchoring agent, wherein the sustained-release pre-concentrate exists as a lipid liquid phase in the absence of aqueous fluid and forms into a liquid crystal upon exposure to aqueous fluid. The sustained-release lipid pre-concentrate is configured to enhance the sustained release of cationic pharmacologically active substance through ionic interaction between the anionic anchoring agent and the cationic pharmacologically active substance.
