Ha Na Yu,Hye Jung Baik,Won Kyu Yang,Jin Young Ko,Sung Bum Jung,Sung Won An,Min Hyo Ki
申请号：
US14440058
公开号：
US20150265535A1
申请日:
2013.12.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed is a sustained-release lipid pre-concentrate, comprising: a) at least one liquid crystal former b) at least one neutral phospholipid c) at least one liquid crystal hardener and d) at least one anionic anchoring agent, wherein the sustained-release pre-concentrate exists as a lipid liquid phase in the absence of aqueous fluid and forms into a liquid crystal upon exposure to aqueous fluid. The sustained-release lipid pre-concentrate is configured to enhance the sustained release of cationic pharmacologically active substance through ionic interaction between the anionic anchoring agent and the cationic pharmacologically active substance.
