Transition metal-based selective functionalization of chalcogens in biomolecules

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专利权人:

Massachusetts Institute of Technology

发明人:

Buchwald, Stephen L.,Pentelute, Bradley L.,Spokoyny, Alexander M.,Vinogradova, Ekaterina V.,Zhang, Chi

申请号：

AU2015289709

公开号：

AU2015289709A1

申请日:

2015.07.15

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

Disclosed are methods of selective cysteine and selenocysteine modification on peptide/protein molecules under physiologically relevant conditions. The methods feature several advantages over existing methods of peptide modification, such as specificity towards thiols and selenols over other nucleophiles (e.g., amines, hydroxyls), excellent functional group tolerance, and mild reaction conditions.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/