Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

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专利权人:

INC.;OPTIMER PHARMACEUTICALS

发明人:

CHIU, YU-HUNG,CHE, TESSIE, MARY,ROMERO, ALEX,ICHIKAWA, YOSHI,SHUE, YOUE-KONG

申请号：

NZ57869708

公开号：

NZ578697A

申请日:

2008.01.22

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is a crystalline polymorph of Formula I comprising tiacumicin (also known as lipiarmycin and fidaxomicin), wherein the polymorph is characterised by a powder x-ray diffraction pattern with at least peaks at diffraction angles 2-theta of 7.7, 15.0 and 18.8 plus or minus 0.2. The polymorph of Formula I is useful for treating bacterial infections such as a gastrointestinal infection of Clostridium difficile.

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