A compound having Formula I, its individual enantiomers, individual diastereomers, and individual geometric isomers, individual tautomers or their pharmaceutically acceptable salts: wherein: R is H, C1-10 alkyl, C3-10 cycloalkyl, -OR6, NR7R8 , halogen, nitrile, nitrogen dioxide, C (O) R9, aryl or heterocycle； R1 is H, C1-10 alkyl, C3-10 cycloalkyl, -OR10, NR11R12, halogen, nitrile, nitrogen dioxide, C (O) R13, aryl or heterocycle； R2 is H, C1-10 alkyl, halogen, aryl or heterocycle； R3 is C1-10 alkyl, C3-10 cycloalkyl, -OR14, NR15R16, halogen, nitrile, nitrogen dioxide, C (O) R17, aryl or heterocycle； R4 is C1-10 alkyl, C3-10 cycloalkyl, -OR18, NR19R20, halogen, nitrile, nitrogen dioxide, C (O) R21, aryl or heterocycle； R5 is C1-10 alkyl, C3-10 cycloalkyl, -OR22, NR23R24, halogen, nitrile, nitrogen dioxide, C (O) R25, aryl or heterocycle； a is 0, 1, 2 or 3； b is 0, 1, 2 or 3； c is 0, 1, 2 or 3； R6 is H, C3-10 cycloalkyl or C1-10 alkyl； R7 is H or C1-10 alkyl； R8 is H or C1-10 alkyl； R9 is H, C3-10 cycloalkyl, -OH, -O-C3-10 cycloalkyl, -O-C1-10 alkyl or C1-10 alkyl； R10 is H, C3-10 cycloalkyl or C1-10 alkyl； R11 is H or C1-10 alkyl； R12 is H or C1-10 alkyl； R13 is H, C3-10 cycloalkyl, -OH, -O-C3-10 cycloalkyl, -O-C1-10 alkyl or C1-10 alkyl； R14 is H, C3-10 cycloalkyl or C1-10 alkyl； R15 is H or C1-10 alkyl； R16 is H or C1-10 alkyl； R17 is H, C3-10 cycloalkyl, -OH, -O-C3-10 cycloalkyl, -O-C1-10 alkyl or C1-10 alkyl； R18 is H, C3-10 cycloalkyl or C1-10 alkyl； R19 is H or C1-10 alkyl； R20 is H or C1-10 alkyl； R21 is H, C3-10 cycloalkyl, -OH, -O-C3-10 cycloalkyl, -O-C1-10 alkyl or C1-10 alkyl； R22 is H, C3-10 cycloalkyl or C1-10 alkyl； R23 is H or C1-10 alkyl； R24 is H or C1-10 alkyl； and R25 is H, C3-10 cycloalkyl, -OH, -O-C3-10 cycloalkyl, -O-C1-10 alkyl or C1-10 alkyl.Un compuesto que tiene la Fórmula I, sus enantiómeros individuales, diasteroisómeros individuales, e isómeros geométricos individuales, tautómeros individuales o sus sales farmacéuticamente aceptables: en
