PROBLEM TO BE SOLVED: To provide ezetimibe-containing pharmaceutical compositions that can inhibit moisture absorption even in highly humid conditions and can also inhibit decrease of hardness, and production methods thereof to provide hardness decreasing inhibitors of an ezetimibe-containing pharmaceutical composition, and methods of inhibiting hardness decrease thereof as well as to provide moisture-absorption inhibitors of ezetimibe-containing pharmaceutical composition, and methods of inhibiting moisture-absorption thereof.SOLUTION: The present invention provides an ezetimibe-containing pharmaceutical composition comprising ezetimibe and a polyvinyl alcohol, a production method of the ezetimibe-containing pharmaceutical composition comprising contacting ezetimibe with a polyvinyl alcohol, and the like.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】高湿度条件下でも吸湿を抑制することができ、硬度の低下も抑制することが可能なエゼチミブ含有医薬組成物及びその製造方法、エゼチミブ含有医薬組成物の硬度低下抑制剤及び硬度低下抑制方法、並びにエゼチミブ含有医薬組成物の吸湿抑制剤及び吸湿抑制方法を提供する。【解決手段】エゼチミブと、ポリビニルアルコールとを含むエゼチミブ含有医薬組成物、エゼチミブと、ポリビニルアルコールとを接触させる工程を含むエゼチミブ含有医薬組成物の製造方法などである。【選択図】なし
