Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 isa monocyclic heteroaryl group, and including stereoisomers, geometric isomers,tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof,are useful for modulating the activity of lipid kinases including PI3K, and fortreating disorders such as cancer mediated by lipid kinases. Methods of usingcompounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, preventionor treatment of such disorders in mammalian cells, or associated pathologicalconditions, are disclosed. [Insert Formula Ic and Id]
