您的位置: 首页 > 农业专利 > 详情页

Benzoxazepin P13K inhibitor compounds and methods of use
专利权人:
Steven Do;Nicole Blaquiere;Chudi Ndubaku;Alan G. Olivero;Robert Heald;Danette Dudley;Stephen Price;Adrian Folkes;Timothy Heffron;Mark Jones;Lan Wang;Steven Staben;Aleksandr Kolesnikov
发明人:
Nicole Blaquiere,Steven Do,Danette Dudley,Adrian Folkes,Robert Heald,Timothy Heffron,Mark Jones,Aleksandr Kolesnikov,Chudi Ndubaku,Alan G. Olivero,Stephen Price,Steven Staben,Lan Wang
申请号:
US12890812
公开号:
US08242104B2
申请日:
2010.09.27
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Benzoxazepin compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2 or N; Z3 is CR3 or N; Z4 is CR4 or N; and B is a pyrazolyl, imidazolyl, or triazolyl ring fused to the benzoxepin ring, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充