Steven Do;Nicole Blaquiere;Chudi Ndubaku;Alan G. Olivero;Robert Heald;Danette Dudley;Stephen Price;Adrian Folkes;Timothy Heffron;Mark Jones;Lan Wang;Steven Staben;Aleksandr Kolesnikov
发明人:
Nicole Blaquiere,Steven Do,Danette Dudley,Adrian Folkes,Robert Heald,Timothy Heffron,Mark Jones,Aleksandr Kolesnikov,Chudi Ndubaku,Alan G. Olivero,Stephen Price,Steven Staben,Lan Wang
申请号：
US12890812
公开号：
US08242104B2
申请日:
2010.09.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Benzoxazepin compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N； Z2 is CR2 or N； Z3 is CR3 or N； Z4 is CR4 or N； and B is a pyrazolyl, imidazolyl, or triazolyl ring fused to the benzoxepin ring, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
