SON, HOE JOO,손회주,PARK, YONG KYU,박용규,KIM, YOUNG MIN,김영민,HWANG, JAE MIN,황재민,KIM, WON SUN,김원선,SON, HOE JOOKR,PARK, YONG KYUKR,KIM, YOUNG MINKR,HWANG, JAE MINKR,KIM, WON SUNKR
申请号：
KR1020140087416
公开号：
KR1020160008026A
申请日:
2014.07.11
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a method for manufacturing a Rosuvastatin calcium salt by using a Rosuvastatin tert-butyl amine salt, and to a method for manufacturing a high purity Rosuvastatin calcium salt, which has impurities less than 0.1% of a diastereomer. The manufacturing method of a high purity Rosuvastatin calcium salt comprises the steps of: 1) manufacturing a compound represented by chemical formula III by reducing a compound represented by chemical formula IV； 2) manufacturing a compound represented by chemical formula II by adding t-butyl amine； and 3) manufacturing a compound represented by chemical formula I by adding a calcium ion to the compound represented by chemical formula II.본 발명은 로수바스타틴 tert-부틸아민 염을 이용하여 로수바스타틴 칼슘염을 제조하는 방법에 관한 것으로, 0.1% 미만의 부분입체 이성체의 불순물을 갖는 고순도의 로수바스타틴 칼슘염을 제조하는 방법에 관한 것이다.
