USE OF CART19 TO DEPLETE NORMAL B CELLS TO INDUCE TOLERANCE

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专利权人:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人:

LEVINE BRUCE L.,KALOS MICHAEL D.,JUNE CARL H.

申请号：

IN139DEN2015

公开号：

IN139DEN2015A

申请日:

2015.01.07

申请国别(地区):

IN

年份:

2015

代理人:

摘要：

The present invention provides compositions and methods for inducing tolerance in a human. The invention includes administering a genetically modified T cell expressing a CAR wherein the CAR comprises an antigen binding domain a transmembrane domain a costimulatory signaling region and a CD3 zeta signaling domain.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/