Use of CART19 to deplete normal B cells to induce tolerance

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专利权人:

The Trustees of the University of Pennsylvania

发明人:

Levine, Bruce L.,Kalos, Michael D.,June, Carl H.

申请号：

AU2013289984

公开号：

AU2013289984B2

申请日:

2013.07.12

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

The present invention provides compositions and methods for inducing tolerance in a human. The invention includes administering a genetically modified T cell expressing a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/