您的位置: 首页 > 农业专利 > 详情页

Fused pyrimidine derivatives
专利权人:
Hoffmann-La Roche Inc.
发明人:
Bjoern Bartels,Roland Jakob-Roetne,Anja Limberg,Werner Neidhart,Hasane Ratni,Michael Reutlinger,Sandra Steiner
申请号:
US16244405
公开号:
US10730881B2
申请日:
2019.01.10
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention relates to a compound of formula IwhereinR1 is phenyl, lower alkyl, C3-6-cycloalkyl, —;CH2—;C3-6-cycloalkyl or bridged C4-6-cycloalkyl, substituted by one, two or three halogen atoms, or by lower alkyl or lower alkyl substituted by halogen;R2 is a five or six membered heteroaryl group, selected fromwhereinR6 is hydrogen, lower alkyl, halogen or lower alkoxy; andR7 is hydrogen, lower alkoxy or halogen;R3 is lower alkyl or lower alkyl substituted by hydroxy:R4 is hydrogen or lower alkyl;R5 is hydrogen or lower alkyl;n is 1 or 2;-( )n- is —;CH2—; or —;CH2CH2—; for n being 1 or 2;or to a pharmaceutically active acid addition salt thereof, to a racemic mixture or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereofThe compounds may be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充