您的位置: 首页 > 农业专利 > 详情页

Fused pyrimidine derivatives
专利权人:
Hoffmann-La Roche Inc.
发明人:
Bjoern Bartels,Roland Jakob-Roetne,Anja Limberg,Werner Neidhart,Hasane Ratni,Sandra Steiner,Michael Reutlinger
申请号:
US16231177
公开号:
US10669276B2
申请日:
2018.12.21
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention relates to compounds of formula I,whereinR1 is phenyl, lower alkyl, C3-6-cycloalkyl, —;CH2—;C3-6-cycloalkyl, or bridged C3-5-cycloalkyl, optionally substituted by one, two or three substituents, selected from halogen, lower alkyl or lower alkyl substituted by halogen;R2 is hydrogen, halogen, lower alkoxy, lower alkyl substituted by halogen or lower alkoxy substituted by halogen;R3 is a five membered heteroaryl group, selected fromwhereinR6 is hydrogen or lower alkyl;R7 is halogen or lower alkyl;R8 is hydrogen or lower alkyl;R9 is hydrogen or lower alkyl;R4 is lower alkyl or lower alkyl substituted by hydroxy;R5/R5′; is independently from each other hydrogen or lower alkyl;-( )n- is —;CH2—; or —;CH2CH2—; for n being 1 or 2;X is CH or N;or to pharmaceutically active acid addition salts thereof, to racemic mixtures or to its corresponding enantiomers and/or optical isomers and/or stereoisomers thereof.The compounds may be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充