PAYNE, AIMEE S.,ELLEBRECHT, CHRISTOPH T.,BHOJ, VIJAY,MILONE, MICHAEL C.
申请号：
CA2984484
公开号：
CA2984484A1
申请日:
2015.05.01
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention includes compositions comprising at least one chimericautoantibody receptor (CAAR) specific for anautoantibody, vectors comprising the same, compositions comprising CAARvectors packaged in viral particles, and recombinant Tcells comprising the CAAR. The invention also includes methods of making agenetically modified T cell expressing a CAAR(CAART) wherein the expressed CAAR comprises a desmoglein extracellulardomain.
